Selective COX-2 inhibitor ameliorates osteoarthritis by repressing apoptosis of chondrocyte
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چکیده
منابع مشابه
Selective COX-2 inhibitor ameliorates osteoarthritis by repressing apoptosis of chondrocyte
BACKGROUND Celecoxib has a positive effect on human osteoarthritic cartilage, but the mechanisms remain unclear. The aim of this study was to test whether celecoxib could inhibit the apoptosis of chondrocyte and ameliorate type II collagen synthesis to relieve symptoms of OA (osteoarthritis). MATERIAL/METHODS 130 Wistar rats were randomly divided into 4 groups as celecoxib (CE), ibuprofen (IB...
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متن کاملChondrocyte Apoptosis in the Pathogenesis of Osteoarthritis
Apoptosis is a highly-regulated, active process of cell death involved in development, homeostasis and aging. Dysregulation of apoptosis leads to pathological states, such as cancer, developmental anomalies and degenerative diseases. Osteoarthritis (OA), the most common chronic joint disease in the elderly population, is characterized by progressive destruction of articular cartilage, resulting...
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ژورنال
عنوان ژورنال: Medical Science Monitor
سال: 2012
ISSN: 1234-1010
DOI: 10.12659/msm.882901